Bioinformatician | Guy's and St Thomas' NHS Foundation Trust

Applications are invited for a Bioinformatics developer based in the Clinical Genetics and Genomics Laboratory in the Royal Brompton Hospital. This is a predominantly on-site role where the applicant will be part of the bioinformatics team responsible for the delivery of the genetics diagnostic service and the development of further bioinformatic tools. The post will be funded by the Trust and will be closely allied to several interdisciplinary collaborative projects between clinicians, IT, scientists and bioinformaticians, working with colleagues at the South East Genomic Laboratory Hub and GMSA, as well as our academic partners in Imperial College London and Kings College London, throughout the UK and more widely internationally. The post-holder will ideally have some background in human molecular genetics and bioinformatics with strong evidence of software development skills.

Key responsibilities will include

Implementation of data processing and data warehousing tools and database development. Applicants will be involved in optimising and streamlining workflows to simplify and speed up data analysis for a large and growing dataset, developing tools to aid the services whilst ensuring alignment with UKAS accreditation. It is expected that the post holder will contribute to patient-orientated research projects, collate data.

To take an active role in the continued development and improvement of the bioinformatic tools for DNA variant annotation and data reporting for the analysis of genetic variants which underlie inherited disorders

Develop scripts and applications that interface with databases for data gathering and presentation purposes.

· Develop, monitor and assess systems to ensure that diagnostics and research is conducted in accordance with Good Clinical Practice (GCP) and Clinical and Research Governance.

· Assist with the development and implementation of Standard Operating Procedures (SOPs) for all activity carried out by the bioinformatics team, taking account of local policies and procedures.

· Ensure compliance to best practice policies including partaking in code review, documentation, testing and validation.

· Participate in local, national and international workshops and meetings, including presenting findings

Assist in the development of public and patient engagement activities.

· Work closely with referring clinicians, clinical scientists, genetic technologists and research assistants in the group.

Be responsible for high quality and high throughput data analysis, documentation and presentation of results.

Update and curate software and annotation resources in use by the Clinical Genetics and Genomics Laboratory.

Participate in the maintenance and servicing of software used by the group.

The Royal Brompton & Harefield Hospitals are part of Guy’s and St. Thomas’ NHS Foundation Trust, with the Heart and Lung Clinical Care Group forming the largest heart and lung centre in the UK and among the largest in Europe. We are a partnership of specialist hospitals which are known throughout the world for our expertise, standard of care and research success. The Clinical Genetics and Genomics Laboratory is also part of the NHSE South East Genomic Laboratory hub and is one of four cardiac and one of three respiratory laboratories, delivering the specialist testing nationally.

The Clinical Genetics and Genomics Laboratory in the Royal Brompton has generated deep expertise in cardiovascular (CV) and respiratory genetics through a large programme of work over the last 7 years and has established infrastructure, expertise and variant repositories on site. The CGGL has developed sophisticated bioinformatic tools and pipelines for the analysis and reporting of different types of sequence data and is actively involved in research to develop new technologies. The diagnostic service collaborates closely with the National Heart and Lung Institute (NHLI), Imperial College London.

Organisational Values

Ourvalueshelp us to define and develop our culture,what we doandhow we do it. It is important that you understand and reflect these values throughout your employment with the Trust.

• To take an active role in the continued development and improvement of the bioinformatic tools for DNA variant annotation and data reporting for the analysis of genetic variants which underlie inherited disorders.
• Develop scripts and applications that interface with databases for data gathering and presentation purposes.
• Develop, monitor and assess systems to ensure that diagnostics and research is conducted in accordance with Good Clinical Practice (GCP) and Clinical and Research Governance.
• Assist with the development and implementation of Standard Operating Procedures (SOPs) for all activities carried out by the bioinformatics team, taking account of local policies and procedures.
• Ensure compliance to best practice policies, including partaking in code review, documentation, testing and validation.
• Assist and perform regulatory audits and inspections towards UKAS accreditation of the laboratory and deal with any issues/actions necessary to maintain the high quality standards of the clinical genetics diagnostic service.
• Ensure that Health and Safety guidelines are adhered to and that risk assessments are conducted prior to research studies being undertaken.
• Ensure that all incidents, accidents and hazards are reported according to the incident reporting mechanisms of the Trust.

This advert closes on Wednesday 3 Jun 2026